bioRxiv Preprint C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
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چکیده
1 Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA 2 Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA 3 McGovern Institute for Brain Research at MIT, Cambridge, Massachusetts 02139, USA 4 Departments of Brain and Cognitive Science and Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 5 Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA 6 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
منابع مشابه
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.
The clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated genes (Cas) adaptive immune system defends microbes against foreign genetic elements via DNA or RNA-DNA interference. We characterize the class 2 type VI CRISPR-Cas effector C2c2 and demonstrate its RNA-guided ribonuclease function. C2c2 from the bacterium Leptotrichia shahii provides interference against RN...
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تاریخ انتشار 2016